Distinct Modes of Ubiquitination of Peroxisome-targeting
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چکیده
Background: Pex5p translocates the cargo proteins into peroxisomes. Results:Mammalian RING peroxins, the Pex10p Pex12p complex, catalyze Lys-linked, multiple monoubiquitination of Pex5p, assuring efficient export of Pex5p from peroxisomes. Conclusion: Distinct Lysand Cys-linked modes of Pex5p ubiquitination control Pex5p-mediated matrix protein import. Significance: This work provides the first evidence of a functional role of mammalian RING peroxins in Pex5p ubiquitination.
منابع مشابه
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تاریخ انتشار 2014